2型糖尿病消瘦患者预后差

ft•3845•-1expression in nonsmall celllung cancer[J],Int JCancer,2X1,汪小沅.基因在非小细胞肺癌组织中的表达情况及其与预后和12BAG-1955:317-

322.化疗疗效的相关性中国协和医科大学，中国医学科学院，[D].

2005.郭琰.通过信号通路调控胃癌细胞蛋白的表达安4COX-2JNK Bel-2[D].叩13Gotz R,Kramer BW,Camarero G,et aLBAG-1h Io-insufficiency impairs徽医科大学，

2012.lung tumorigenesis[J].BMC Cancer,2004,4:

85.5Ni W,Chen B,Zhou G,et al.Dysregulation of BAG-1in hepatocellular14Jiang H,Wang J,Zhao W.Cox-2innon-small celllung cancer:acarcinoma predictspatient outcomeand mediatesincreased resistancetometa-analysis[J].Clin ChimActa,2013,18:419:26-

32.doxorubicin-induced apoptosisvia NF-kB pathway[JJ.Cell Biochem,15Dursun P,Yuce K,Usubutun A,et aLCyclooxygenase-2expression in2013,1149:2120-

2130.cervical intraepithelialneoplasia IIIIIand squamouscell cervical6Skeen VR,Collard TJ,Southern SL,et al.BAG-1suppresses expression of thecareinoma,and itscorrelation withclincopathologie variablesJI.Int JGynecolkey regulatorycytokine transforminggrowth factorp TGF-piin colorectalCancer,2007J7l:164-

173.tumour cells[J].Oncogene,2013,3238:4490-

4499.16Tawfk OW,Kramer B,Shideler B,et al.Prognostic significanceof7Van derZee JA,Ten HagenTL,Hop WC,et al.Bcl-2associated anthanogen-CD44,platelet-derived growthfactor receptoralpha,and cyclooxygenase2lBag-lexpression andprognostic valuein pancreatichead andperiampullaryexpression inrenal cell carcinoma|J].Arch PatholLab Med,2007,131cancer[JJ.Eur JCancer,2013,492:323-

328.2:261-

267.8Leng XF,Chen MW,Xian L,et al.Combined analysisof mRNAexpressionof吴倩，朱志图，哈敏文，等在非小细胞肺癌中的表达

17.BAGTERCC1,BAG-1,BRCA1,RRM1and TUBB3to predictprognosis inpatients与含伯方案化疗敏感性的关系中国肿瘤临床，with non-small celllung cancerwho receivedadjuvant chemotherapy[J].J[J].2009,362:97-

100.Exp ClinCancer Res,2012,31:

25.doi;

10.1186/1756-9966-31-

25.18Wang YD,Ha MW,Cheng J,et al.The roleof expressionand poly-moiphismof theBAG-1gene inresponse toplatinum-based chemotherapeuticsin9Wood J,Pring M,Eveson JW,et al.Co-overexpression ofBag-1and heatshockNSCLC[J].Oncol Rep,2012,274:979-protein70in humanepidermal squamouscellcarcinoma:Bag-1-mediatedresistance to5-fluorouracil-induced apoptosis[J].Br J

986.Cancer,2011,1049:1459-

1471.19Liu H,Liang Y,LI Y,et al.Gene silencingof BAG-1modulates apoptotic10Porichi O,Nikolaidou ME,Apostolaki A,et aLIsomorph expressionofBAG-1genes andsensitizes lungcancer celllines tocisplatin-induced apoptosis[J].gene,ER andPR inendometrial cancer[JJ.AnticancerCancer BiolTher,2010,910:832-Res,2010,3010:4103-

4108.

840.11Dzhagalov I,Dunkle A,He YW.The anti-apoptotic Bcl-2family memberMel收稿日期:2014-05-10;修回日期2014-09-20本文编辑；-1promotes Tlymphocyte survivalat multiplestages赵跃翠[J].J Immunol,2008,1811:521-

528.医学新闻・•型糖尿病消瘦患者预后差2由于常将体质指数患者排除在外，以往研究中关于与糖尿病死亡率之间的关系不一定能全面反映整个人群的情况BMIG8kg/ni2BMI为此，来自日本东京大学公共卫生学院的教授及其团队进行了一项研究，调查型糖尿病患者与死亡率之间的关系该研究结果Hirohito Sono2BMI在线发表于年月日的杂志201499The Journalof ClinicalEndocrinologyMetabolism该研究中，教授等对日本糖尿病并发症研究和日本老年糖尿病干预研究中例型糖尿病患者年随访数据进行汇总分析，排除有心血Sone

262026.3管疾病或癌症病史的患者研究重点为全因死亡率校正年龄、吸烟情况、业余时间体力活动和其他混杂因素后，利用回归模型评估不同Cox BMI患者全因死亡率的风险比该研究按BMI水平将患者分为4组

14.4-

18.4kg/m

25.2%,

18.5〜

22.4kg/m

237.3%.

22.

524.9kg/m

231.0%和

25.0-

37.5kg/m

226.6%组，分析发现，BMIN

18.5kg/m2的患者死亡率间无显著差异与BMI为

22.5-

24.9kg/in患者相比，BMI

18.5kg/m2患者全因死亡率的风险比为排除随访前年的死亡事件后，此风险比仅略有下

2.5895%C

11.38,

4.84o4降该研究提示，为的型糖尿病患者死亡率最低，且肥胖对死亡率无明显影响教授指出，还需要在消瘦型糖尿病患者BMI

18.5~

24.9kg/m22Sone2中行进一步的研究，特别是东亚老年人群中原文见Tanaka S,Tanaka S,Iimuro S,et al.Body massindex andmortality amongJapanese patientswith type2diabetes;Pooled Analysisof theJapan DiabetesComplicationsStudy andthe JapaneseElderly DiabetesIntervention Trial[J].J ClinEndocrinol Metab,2014Sep9:jo

20141855.。